发表在《美国植物科学杂志》上的一项研究表明，橄榄叶提取物可通过帮助平衡血糖来治疗2型糖尿病。
这项研究是由伊斯坦布尔法提赫苏丹穆罕默德大学的AbdurrahimKoçyiğit教授领导的，他告诉《每日沙巴报》说2型糖尿病的主要问题是胰岛素抵抗。
“该研究仅是试管中胰岛素受体活性改变的报道。由于胰岛素受体的功能在2型糖尿病中是正常的，所以这不支持治疗或预防中的作用。”
——罗伊·泰勒（Roy Taylor）纽卡斯尔大学糖尿病研究中心教授说。
根据Koçyiğit的说法，尽管2型糖尿病患者通常大部分时间的胰岛素水平都高于正常水平，但他们的血糖水平也很高。他将其归因于缺乏胰岛素受体，胰岛素受体阻止了葡萄糖进入细胞并被代谢。
多酚类物质从橄榄叶来源可以增加胰岛素的敏感性和活动，以及提高胰腺癌的响应，以帮助身体更好的代谢糖。——Koçyiğit
《橄榄油时报》在2017年曾经报道了伊拉克的一项研究，该研究表明，橄榄叶提取物有望成为控制糖尿病和高胆固醇疾病的安全，经济的替代品。
橄榄叶多酚降低2型糖尿病发生风险的潜力在2013年的一项研究中也得到了揭示，该研究表明该提取物改善了处于发育危险中的超重中年男性的胰岛素敏感性和胰腺β细胞分泌能力这种病。
Koçyiğit没有回应对此研究发表评论的要求。但是，纽卡斯尔大学糖尿病研究中心的教授罗伊·泰勒（Roy Taylor）告诉《橄榄油时报》，橄榄叶提取物可能在2型糖尿病的治疗或预防中不发挥重要作用。
橄榄油可以是有益的，前提是它可以被视为动物脂肪的替代品。”“就其本身而言，据我所知，没有可靠的证据，它赋予任何特别的好处，如果采取除了正常的饮食会导致体重增加。”
为了进行Koçyiğit的研究，从土耳其西部的Tekirdag省的一棵橄榄树上采集了成熟的叶子，进行了长达一年的细胞培养研究。
在尝试了多种提取方法后，研究小组得出结论，使用甲醇是获得高浓度，标准化和稳定形式的多酚橄榄苦苷的最有效方法。（在伊拉克较早的研究中，这也是最佳提取方法。）
需要指出的是，需要对动物和人类进行进一步的试验，以确定正确的剂量，以实现最大的益处并减少任何风险。
Koçyiğit声称与医生的讨论表明，糖尿病患者的青睐橄榄叶的产品比其他的保健品，并建议谁没有考虑橄榄叶为他们的2型糖尿病患者有益，即使糖尿病患者认为它提供其他健康益处。
原文如下
A study published in the American Journal of Plant Sciences suggested that olive leaf extract could play a role in treating Type 2 diabetes by helping to balance blood sugar.
The study was led by professor Abdurrahim Koçyiğit from Istanbul’s Fatih Sultan Mehmet University who told the Daily Sabah newspaper that the main issue with Type 2 diabetes was insulin resistance.
“The study is merely a report of alteration in insulin receptor activity in the test tube. As insulin receptor function is normal in Type 2 diabetes (despite much confusing information) this is not supportive of a role in treatment or prevention.”
- Roy Taylor, professor at the Newcastle University the diabetes research center
According to Koçyiğit, although sufferers of Type 2 diabetes generally have higher than normal insulin levels most of the time, they also display high blood sugar levels. He attributed this to a lack of insulin receptors which prevents glucose from entering cells and being metabolized.
Koçyiğit suggested that polyphenols sourced from olive leaves can increase insulin sensitivity and activity, as well as improving pancreatic responsiveness to assist the body in better metabolizing sugar.
The study confirmed that olive leaves had antimicrobial, antihypertensive and anti-inflammatory properties. It was noted that the anti-hyperglycemic benefits of the leaves were greater in extract form than when brewed as a type of tea.
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In 2017, Olive Oil Times reported on a study from Iraq which suggested olive leaf extract held promise as a safe and economical alternative to control diabetes and hyper cholesterol disorders.
The potential of olive leaf polyphenols for reducing the risk of developing Type 2 diabetes also came to light in a 2013 study which suggested that the extract improved insulin sensitivity and pancreatic β‑cell secretory capacity in overweight middle-aged men who were at risk of developing the disease.
Koçyiğit did not respond to a request for comment on the study. However, Roy Taylor, a professor at the diabetes research center at Newcastle University, told Olive Oil Times that olive leaf extract may not play an important role in the treatment or prevention of Type 2 diabetes.
“The study is merely a report of alteration in insulin receptor activity in the test tube,” he said. “As insulin receptor function is normal in Type 2 diabetes (despite much confusing information) this is not supportive of a role in treatment or prevention.”
“However, olive oil can be beneficial provided it is seen as an alternative to animal fats,” he added. “In itself, I know of no sound evidence that it confers any special benefit, and if taken in addition to normal eating it will lead to weight gain.”
For Koçyiğit’s research, mature leaves were gathered from an olive tree in Turkey’s western province of Tekirdag for a year-long cell culture study.
After experimenting with various extraction methods, the research team concluded that using methanol was the most effective method of obtaining a highly concentrated, standardized and stable form of the polyphenol oleuropein. (This was also cited as the best extraction method during an earlier study in Iraq.)
It was noted that further trials on animals and humans were required to ascertain correct dosages for achieving maximum benefits and reducing any risks.
Koçyiğit claimed that discussion with doctors had shown that diabetics favored olive leaf products over other health supplements and suggested that even diabetics who did not consider olive leaf as being beneficial to their Type 2 diabetes believed it delivered other health benefits.
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