李晓,河北辛集人,西北农林科技大学副教授、博导。中国畜牧兽医学会动物生理学分会会员、动物遗传育种学分会会员,在Frontiers开设Marbling fat in livestock专题,为Frontiers in Cell and Developmental Biology/ Molecular Biosciences/ Genetics/ Veterinary Sciences等杂志组稿。

辛集养黑猪大户(李晓河北辛集人)(1)

李晓,河北辛集人,西北农林科技大学副教授、博导,猪业 人造肉专家。

一、研究方向

  优良猪肉品质形成的生理学和遗传学基础;新型猪生长调节剂的研发和推广;细胞培养肉流程的设计和优化;特色品种遗传多样性调查。

二、教授课程

  动物细胞生物学的教学与科研工作,参与细胞生物学精品课程和双语课程的建设。

三、教育简历

  2001-2005 本科 南京农业大学动物医学院;

  2005-2011 硕博连读 南京农业大学农业部动物生理生化重点开放实验室。

  2009.01-2011.01 美国弗吉尼亚理工大学、美国康奈尔大学 合作科研。

  2017.11-2018年11 美国华盛顿州立大学 交流访问。

  2012.01-至今 西北农林科技大学动物科技学院。

辛集养黑猪大户(李晓河北辛集人)(2)

西北农林科技大学

四、科研项目

  1、发酵桑叶改良猪胴体品质的应用研究(2019NY-078),陕西省重点研发计划—一般项目,2019-2020,10万元

  2、MyHC-AS调控猪骨胳肌II型MyHCs转录的机制研究(31501925),国家自然科学基金青年科学基金项目,2016-2018,19万元(直接经费)

  3、PPARγ-AMPK差异性调控猪脂肪沉积的作用机制(2452019205),中央高校基本科研业务费——科技创新一般项目,2019-2020,7万元

  4、IGF2-AS调控猪肌肉IGF2启动子活性的分子机制(2014JQ3103),陕西省自然科学基金青年项目,2014-2015,3万元

  5、Wnt/β-catenin调节MSTN启动子活性的分子机制(2014M562465),中国博士后科学基金第56批面上资助(二等),2014-2016,5万元

  6、伪受体BAMBI在myostatin抑制猪骨骼肌卫星细胞增殖过程中的作用(2014YB005),中央高校基本科研业务费——科技创新一般项目,2014-2016,10万元

  7、猪miR-17-92簇启动子克隆及其活性分析(2012BSJJ095),西北农林科技大学博士科研启动基金暨陕西省专项配套经费,2013-2015,10万元

五、论文论著

  1、Mingle Dou, Ying Yao, Ying Peng, Meixue Xu, Xin’e Shi, Gongshe Yang, Xiao Li*. The long noncoding RNA MyHC IIA/X-AS contributes to skeletal muscle myogenesis and maintains the fast fiber phenotype. Journal of Biological Chemistry, 2020 Apr 10; 295(15):4937-4949, DOI: 10.1074/jbc.RA119.010498

  2、Xiaoyu Wang1, Huifang Zhang1, Xin’E Shi, Gongshe Yang, Shiduo Sun, Xiao Li*. Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and FASN, respectively. Acta Biochimica et Biophysica Sinica (Shanghai), 2020 May 22 accepted, DOI:10.1093/abbs/gmaa111

  3、Xiaoyu Wang, Meixue Xu, Ying Peng, Qimuge Naren, Yanting Xu, Xin Wang, Gongshe Yang, Xin’E Shi, Xiao Li*. Triptolide enhances lipolysis of adipocytes by enhancing ATGL transcription via upregulation of p53. Phytotherapy Research, 2020 July 02 online, DOI: 10.1002/ptr.6779

  4、Xiaoyu Wang1, Jing Yang1, Ying Yao, Xin’E Shi, Gongshe Yang, Xiao Li*. AQP3 facilitates proliferation and adipogenic differentiation of porcine intramuscular adipocytes. Genes, 2020 Apr 22;11(4). pii: E453. doi: 10.3390/genes11040453

  5、Lujie Fan, Ying Peng, Dan Wu, Jianhong Hu, Xin’E Shi, Gongshe Yang, Xiao Li*. Morus nigra L. leaves improve the meat quality in finishing pigs. Journal of animal physiology and animal nutrition, 2020 Aug 28 online, DOI: 10.1111/jpn.13439

  6、Yixin Chu, Ying Yao, Youbo Zhu, Xin’e Shi, Shiduo Sun, Xiao Li*. MiR-370 enhances cell cycle and represses lipid accumulation in porcine adipocytes. Animal Biotechnology, 2019, Dec 03; 1-9, doi: 10.1080/10495398.2019.1697278

  7、Lujie Fan, Ying Peng, Dan Wu, Jianhong Hu, Xin’e Shi, Gongshe Yang, Xiao Li*. Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model. Journal of Ethnopharmacology, 2020 Mar 1; 249: 112416. doi.org/10.1016/j.jep.2019.112416

  8、Xiao Li, Xing Fu, Gongshe Yang, Min Du*. Review: Enhancing intramuscular fat development via targeting fibro-adipogenic progenitor cells in meat animals. Animal, 2020 Feb;14(2):312-321. doi: 10.1017/S175173111900209X

  9、武丹,李晓*.冷鲜肉保鲜过程中的微生物污染及其预防措施.食品工业科技. 2019, 40 (21):320-325

  10、Lujie Fan, Mingle Dou, Xiaoyu Wang, Qichun Han, Bo Zhao, Jianhong Hu, Gongshe Yang, Xin’E Shi, Xiao Li*. Fermented corn-soybean meal elevated IGF1 levels in grower-finisher pigs. Journal of Animal Science, 2018, Sep 8th, 96(12): 5144-5151. doi: 10.1093/jas/sky361

辛集养黑猪大户(李晓河北辛集人)(3)

西北农林科技大学

  11、Xiao Li1, Youbo Zhu1, Huifang Zhang, Guangjun Ma, Guofang Wu, Aoqi Xiang, Xin'E Shi, GongShe Yang, Shiduo Sun*. MicroRNA-106a-5p inhibited C2C12 myogenesis via targeting PIK3R1 and modulating the PI3K/AKT signaling. Genes (Basel), 2018, July, 2, 9(7): E333

  12、樊路杰, 窦鸣乐, 王小宇, 李泽, 史新娥, 李晓*. 宰后肌肉抗氧化能力与肌肉品质的关系. 动物营养学报, 2018, May, 15, 30(5):1676-1680.

  13、YouLei Li#, Xiao Li#, TianTuan Jiang, JiaMeng Fan, XueLi Zheng, XinE Shi, TaiY ongYu, GuiYan Chu, GongShe Yang. An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of Rosiglitazone and CL316,243. International Journal of Molecular Science, 2017, 18(5): pii: E1002

  14、Xiao Li#, Jing Yang#, Youbo Zhu, Yuan Liu, Xin’e Shi, Gongshe Yang. Maternal high-fat intake dynamically programmed mRNA m6A modifications in adipose and skeletal muscle tissues in offspring. International Journal of Molecular Science, 2016, 17(8): pii: E1336

  15、Xiao Li#, Kuilong Huang#, Fenfen Chen, Wanhua Li, Shiduo Sun, Xin-E Shi, Gongshe Yang. Verification of suitable and reliable reference genes for quantitative real-time PCR during adipogenic differentiation in porcine intramuscular stromal-vascular cells. Animal, 2016, 10(6): 947-952

  16、Qiangling Zhang, Xin-E Shi, Chengchuang Song, Shiduo Sun, Gongshe Yang, Xiao Li*. BAMBI promotes C2C12 myogenic differentiation by enhancing Wnt/β-catenin signaling. International Journal of Molecular Science, 2015, 16(8), 17734-17745

  17、Xiao Li#, Jinquan Wang#, Zheng Jiang, Feng Guo, Paul D Soloway, Ruqian Zhao. Role of PRDM16 and its PR domain in the epigenetic regulation of myogenic and adipogenic genes during transdifferentiation of C2C12 cells. Gene. 2015, 570(2), 191-198

  18、Chengchuang Song, Guofang Wu, Aoqi Xiang, Qiangling Zhang, Wanhua Li, Gongshe Yang, Shiduo Sun*, Xiao Li*. Over-expression of miR-125a-5p inhibits proliferation in C2C12 myoblasts by targeting E2F3. Acta Biochimica et Biophysica Sinica(Shanghai), 2015, 47(4), 244-249

  19、Xiao Li#, Li Qiu, Zengqi Yang, Ruyi Dang, Xinglong Wang. Emergency vaccination alleviates highly pathogenic porcine reproductive and respiratory syndrome virus infection after contact exposure. BMC Veterinary Research, 2013, 9:26

  20、Jinquan Wang#, Xiao Li#, Xiaojing Yang, Qinwei Sun, Ruihua Huang, Jun Xing, Ruqian Zhao. Maternal dietary protein induces opposite myofiber type transition in Meishan pigs at weaning and finishing stages. Meat Science. 2011, 89: 221-227

  21、Xiao Li, Xiaojing Yang, Bin Shan, Jian Shi, Dong Xia, J Wegner, Ruqian Zhao. Meat quality is associated with muscle metabolic status but not contractile myofiber type composition in premature pigs. Meat Science. 2009, 81: 218-223

中国各农业大学教授简介

  徐秀容(女),湖北英山人,西北农林科技大学副教授,牛羊专家

  孙青竹(女),西北农林科技大学教授、博导,陕西省科技新星

  蓝贤勇,西北农林科技大学教授、博导,牛羊遗传育种专家

  刘小林,西北农林科技大学动科学院,教授、博导,动物育种专家

  胡建宏,西北农林科技大学教授,博导,动物生殖生理专家

  郑鹏,东北农业大学讲师,动物繁育专家

  姚新奎,新疆农业大学动物科学院教授、博导,马业专家

  董坤,云南农业大学教授、博导,蜂学系系主任,蜂业专家

  李大彪,内蒙古农业大学教授、博导,牛羊营养与微生态专家

  韩向敏,甘肃农业大学教授、硕导,牛羊养殖专家

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