Pal-GHK棕榈酰寡肽，CAS号：147732-56-7
云希棕榈酰三肽-1/棕榈酰寡肽
中文名称：棕榈酰三肽-1/基肽3000/棕榈酰寡肽
英文名称：Palmitoyl Tripeptide-1/Matrixyl 3000 / Pal-GHK
CAS号：147732-56-7 纯度：≥98%
分子量 ：578.80g/mol 分子式 ：C30H54N6O5
Palmitoyl oligopeptide
Palmitoyl oligopeptide (Pal-GHK) is one of the two active ingredients in Matrixyl 3000. It consists of a short chain of three amino acids (a.k.a. GHK peptide or glycine-histidine-lysine) connected to palmitic acid. Palmitic acid is a fatty acid added to improve the peptide's oil solubility and thus skin penetration.
The peptide GHK is a fragment of type I collagen molecule and is believed to serve as a biological indicator of increased degradation of the skin matrix. Indeed, when collagen is degraded, more of its small fragments get created in the body, including GHK. Furthermore, GHK is believed to stimulate the feedback loop triggering the synthesis of new collagen as well as other comPOnents of the skin matrix.
When the key skin matrix-producing cells (fibroblasts) detect increased levels of GHK, they "assume" that the skin matrix is being lost at a higher rate and begin synthesizing it more vigorously. Thus, Pal-GHK (a version of GHK designed for better skin penetration) is intended to stimulate skin matrix replenishment via topical application, leading, presumably, to wrinkle reduction, skin firming and other benefits.
棕榈酰寡肽（也称为棕榈酰五肽，Dermaxyl，Matrixyl和Matrixyl 3000）是一种工程化的氨基肽，当添加到成纤维细胞（关键皮肤细胞）培养物中时，可刺激胶原蛋白，弹性蛋白和葡糖胺聚糖的产生。这些是看起来健康的皮肤的关键成分。
临床证明可通过增加透明质酸和胶原蛋白的产生来减少皱纹深度，棕榈酰寡肽（PO）是合成蛋白，是胶原蛋白与棕榈酸结合的片段，使其具有更大的亲脂性，从而提高了其稳定性并增强了其对人体皮肤的亲和力。与Palmitoyl Pentapeptide-3（棕榈酰五肽3）一样，人们可以将PO视为胶原蛋白的人造前体。
PO是通过研究开发的，目的是鉴定一种与视黄酸相似但无缺点的物质，尤其是在合成胶原蛋白方面。报告的结果如下：体外：使成纤维细胞的胶原蛋白产量增加350％。增加透明质酸成纤维细胞的产量高达146％。体内：使用志愿者的图像分析收集以下统计数据，这些志愿者使用了浓度为3％的Biopeptide-CL的奶油，持续28天。
表面粗糙度-减少17％的平均皱纹深度-减少23％的主要皱纹深度-减少39％皮肤厚度-增加4％皮肤厚度的增加被认为是特别显着的，与老化10年后皮肤厚度减少6％形成对比。PO是有效的活性化妆品成分，没有类维生素A的副作用（包括刺激，脱水或长期毒性和不稳定性）。
PALMITOYL OLIGOPEPTIDE
Palmitoyl Oligopeptide (also known as palmitoyl pentapeptide, Dermaxyl, Matrixyl and Matrixyl 3000) is an engineered amino-peptide that when added to a culture of fibroblasts (key skin cells), stimulates collagen, elastin and glucosaminoglycans production. These are the key components of healthy-looking skin.
Clinically proven to reduce wrinkle depth by increasing hyaluronic acid and collagen production, Palmitoyl Oligopeptide (PO)is a synthetic protein that is a fragment of collagen combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin.
As with Palmitoyl Pentapeptide-3, one could look at PO as a man-made precursor to collagen. PO was developed through research to identify a substance that would behave similarly to retinoic acid but without its drawbacks, especially in regards to synthesizing collagen.
The reported results are as follows: In vitro: Increases collagen production by the fibroblasts by as much as 350%. Increases hyaluronic acid production by the fibroblasts by as much as 146%. In vivo: The following statistics were gathered using image analysis of volunteers who used crèmes containing a 3% concentration of Biopeptide-CL for 28 days. Surface roughness -- Reduced 17% Mean depth of wrinkles -- Reduced 23% Depth of main wrinkle -- Reduced 39% Skin thickness -- Increased 4%.
The increase in skin thickness was considered especially notable and contrasts with the 6% reduction of the skin thickness that occurs after 10 years of aging. PO is a potent active cosmetic ingredient without the adverse effects (including irritation, dehydration or long-term toxicity and instability) characteristic of retinoids.
Used in CSRx Lip Remodeling Treatment, Intensive Eye Therapy Creme, Firming Peptide Eye Creme, and Fresh Pout Lip Balm.
云希棕榈酰三肽-1/棕榈酰寡肽
棕榈酰三肽-1是一种matrikine信号肽，它作用于真皮层，能促进细胞外基质如胶原蛋白和糖胺聚糖的合成，加强真皮层，使皮肤变得更厚，紧致，皱纹得到舒缓，对抗紫外线照射的能力更强。
